2-chloro-3-(1H-imidazol-5-yl)propanoic acid

2-chloro-3-(1H-imidazol-5-yl)propanoic acid - Names and Identifiers

Name	(S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid
Synonyms	NSC 30490 NSC 304903) ((S)-Chloro-1H-imidazole-4-propanoic Acid (S)-a-Chloro-1H-imidazole-4-propanoic Acid 2-chloro-3-(1H-imidazol-5-yl)propanoic acid 1H-Imidazole-5-propanoic acid, α-chloro-, (αS)- (S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid
CAS	17561-26-1
InChI	InChI=1/C6H7ClN2O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1H2,(H,8,9)(H,10,11)/t5-/m0/s1

2-chloro-3-(1H-imidazol-5-yl)propanoic acid - Physico-chemical Properties

Molecular Formula	C6H7ClN2O2
Molar Mass	174.59
Melting Point	170-173°C
Solubility	DMSO (Slightly), Water (Sparingly)
Appearance	Solid
Color	Off-White
Storage Condition	-20°C Freezer
Refractive Index	1.589

2-chloro-3-(1H-imidazol-5-yl)propanoic acid - Introduction

(S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid, also known as 2-chloro-4-imidazolyl-l-alanine, it is an organic compound. The following is a detailed description of its nature, use, preparation and safety information:

Nature:
-Appearance:(S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid is a colorless crystal or white crystalline powder.
-Solubility: It is slightly soluble in water, more soluble in ethanol and Ether solvents.
-chemical properties:(S)-(-)-2-cholo-3-[4(5)-imidazolyl]propionic Acid is an amino Acid derivative, it can be used as an inhibitor of enzymes or as a modifying reagent for important biomolecules.

Use:
-Biochemistry:(S)-(-)-2-choro-3-[4(5)-imidazolyl]propionic Acid is often used in biological and biomedical research, especially in the field of protein modification and enzyme inhibition.
-Drug research and development: It can be used as an intermediate or reagent in drug research and development.

Method:
(S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid is generally synthesized by the following steps:
-The first step: 2-chloro-4-imidazolyl propionic acid is reacted with a chiral esterification reagent to generate a chiral acid chloride.
-The Second step: the chiral Acid chloride is reacted with ammonia water to generate the chiral amide of (S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid.
-the third step: the chiral amide is subjected to Acid hydrolysis reaction to generate (S)-(-)-2-Chloro-3-[4(5)-imidazolyl]propionic Acid.

Safety Information:
- (S)-(-)-2-choro-3-[4(5)-imidazolyl]propionic Acid has certain toxicity to human health and requires careful operation.
-Avoid direct contact with skin or inhalation of powder.
-During use and storage, observe safety procedures and wear appropriate protective equipment, such as lab gloves and safety glasses.
-Waste disposal shall be carried out in accordance with local regulations.

Last Update：2024-04-09 02:00:43